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Prolotherapy is a preferred treatment method for the conditions with erosion, injury, laxity, and partial rupture in the tendons and ligaments.


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Prolotherapy is derived from “proliferation” and can be also called “proliferation therapy”. Prolotherapy is based on a certain technique, in which proliferative and irritating solutions are applied to the injured connective tissue-bone junction. The goal of these injections is to strengthen the weakened tissues and alleviate the pain. The combination of the hypertonic dextrose and lidocaine (local anesthetic) is the most common solution used in the prolotherapy.

This solution creates an inflammatory process at the application site and attracts the regenerative cells to the damaged tissue. This regenerative process lasts approx. 2-3 weeks and clinical improvement is observed after this period. Three to six prolotherapy sessions are implemented in intervals of 2-3 weeks according to the severity of the disorder.

The most important advantage of the prolotherapy is the triggering of the natural recovery mechanisms of the body.


Prolotherapy is preferred in conditions with chronic pain. The pain depends usually on the laxity of the ligaments and muscles spasms in disorders such as lumbar and cervical disc hernia, osteoarthritis, and tendinitis. If the laxity in the ligaments is not treated, the stability of the joints is impaired, the muscle spasms become permanent, and pain becomes chronic.


In respect of the prolotherapeutic approach, the main problem is the laxity of the tendons and ligaments surrounding the joint and the recovery cannot be achieved without the treatment of this laxity. It can be implemented by experienced physiatrists in osteoarthritis, lumbar and cervical disc hernia, tennis and golf elbow, heel spur, sports injuries, chronic cervical, and lumbar pain.


What Should Be Taken Into Consideration During Prolotherapy?

Pain may be augmented in the first days after the therapy. Drugs used for the treatment of edema are recommended after the therapy to increase the success. Drinking plenty of water before and after the session increases the efficacy of the therapy. This treatment cannot be used in patients using anticoagulants and having an infection at the application site. The patient should follow the exercise programs planned by the physiatrist after prolotherapy.